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Claudia Morris, MD, Uncovers Potential New Mechanism of Action for Hydroxyurea
Data presented at the American Society of Hematology (ASH) Annual Meeting and Exposition showed the benefits of using Arginine (Arg) to supplement treatment of vaso-occlusive episdes (VOEs) in patients with sickle cell disease (SCD). While statistically insignificant, they observed a clinically relevant decrease in total parenteral opioid (TPO) and a shortened time to crisis resolution in both intervention groups treated with Arg compared with placebo.
In an interview with HCPLive, lead investigator and presenter Claudia Morris, MD, Childrens Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, shared a novel discovery found during the investigation that hadn’t been addressed in her talk at the conference.
“In our mitochondrial work, we actually uncovered a potential new mechanism of action (MOA) for hydroxyurea,” she explained, “because we saw that the patients who were on hydroxyurea had improved mitochondrial function and lower oxidative stress than the patients who are not on the hydroxyurea.”
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This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.